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Agent 22 may refer to:

Afternoon of a Giraffe by Agent 22.

1. CONTROL agent who paints Afternoon of a Giraffe when under consideration for assignment to investigate forgeries of artworks at the museum. [Mentioned, Episode #42: "Bronzefinger".]

PITS Agent 22.

2. PITS agent assigned to work with Maxwell Smart to thwart a KAOS threat to destroy all fabric thereby rendering the whole world nude. See Main Article. [Portrayed by Andrea Howard, Movie: "The Nude Bomb".]